Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
نویسندگان
چکیده
Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies including cervical cancer and are involved tumor development oncogenesis. Here, we found that circABCB10 was higher 58 tissue sample than the adjacent normal tissues. Higher expression significantly associated with advanced International Federation of Gynecology Obstetrics (FIGO) stage greater lymphatic invasion, worse survival time patients. Function assays showed silencing inhibited cell proliferation, migration invasion capacities. Moreover, demonstrated inhibition upregulated epithelial-mesenchymal transition (EMT)-related proteins E-cadherin downregulated Vimentin expression, which suggested affected EMT signaling pathway cancer. Thus, may contribute to by affecting pathways.
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ژورنال
عنوان ژورنال: Food Science and Technology
سال: 2021
ISSN: ['2331-513X', '2331-5156']
DOI: https://doi.org/10.1590/fst.54521